The long-awaited Bustamante ribosome paper is now out. But, at first glance, this paper doesn't have data on tethered ribosomes. Instead, it has tethered RNA, and tracks the sequential opening of a hairpin by the ribosome. This is still pretty neat, but I'm still breathless to see data about tethered ribosomes. None of the conclusions here appear to be revolutionary (the ribosome moves a codon at a time!!!1!!!1!!), but I'm not a ribo-expert, and there's some interesting looking stuff about the distribution of rate constants during the pausing.
UPDATE: Biocurious has posted a longer review of the paper here.
Wednesday, March 12, 2008
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